| Sketch | Sybil III |
| Jill Clayburgh | ... | Dr. Wilbur |
| Jane Curtin | ... | Sybil Connolly |
| Laraine Newman | ... | Sybil Weintraub |
| Gilda Radner | ... | Colleen Fernman /Sybil Dorsett |
| Anne Beatts | ... | Debra |
| Yvonne Hudson | ... | Debra |
| Marilyn Suzanne Miller | ... | Debra |
| Don Pardo | ... | announcer Voice |
| Karen Roston | ... | Debra |
| Rosie Shuster | ... | Debra |
| Lynn Goldsmith | ... | Debra |