| Sketch | What Really Happened At The "Desperate Housewives" Vanity Fair Photo Shoot |
| Eva Longoria | ... | Teri Hatcher |
| Rachel Dratch | ... | Eva Longoria |
| Darrell Hammond | ... | announcer Voice |
| Seth Meyers | ... | Nicolette Sheridan |
| Amy Poehler | ... | Marcia Cross |
| Bill Hader | ... | Mark |
| Andy Samberg | ... | assistant |
| Jason Sudeikis | ... | Leonard Kelly |
| Kristen Wiig | ... | Felicity Huffman#1 |
| Liz Cackowski | ... | assistant |