October 16, 2021#1
| Cold Opening | NFL Press Conference |
| Pete Davidson | ... | Larry Rucker |
| Andrew Dismukes | ... | equipment manager Live |
| Heidi Gardner | ... | cheerleader Live |
| James Austin Johnson | ... | Jon Gruden Live |
| Colin Jost | ... | Roger Goodell Live |
| Alex Moffat | ... | Mark Davis Live |
| Kyle Mooney | ... | Giuseppe The Stinky Italian Live |
| Chris Redd | ... | Colin Kaepernick Live |
| Cecily Strong | ... | head of P.R. |
| Kenan Thompson | ... | LeVar Burton Live |
| Steve Higgins | ... | announcer Voice |