| Cold Opening | A Message From Dr. Anthony Fauci |
| Beck Bennett | ... | CDC player Live |
| Aidy Bryant | ... | CDC player Live |
| Pete Davidson | ... | CDC player Live |
| Mikey Day | ... | CDC player Live |
| Heidi Gardner | ... | CDC player Live |
| Kate McKinnon | ... | Dr. Anthony Fauci#4 Live |
| Alex Moffat | ... | CDC player Live |
| Kyle Mooney | ... | CDC player Live |
| Ego Nwodim | ... | CDC player#1 Live |
| Chris Redd | ... | CDC player Live |
| Cecily Strong | ... | CDC player |
| Kenan Thompson | ... | CDC player |
| Melissa Villaseñor | ... | CDC player Live |
| Andrew Dismukes | ... | CDC player Live |
| Chloe Fineman | ... | CDC player Live |
| Lauren Holt | ... | CDC player Live |
| Punkie Johnson | ... | CDC player Live |
| Bowen Yang | ... | CDC player#1 Live |
| Steve Higgins | ... | announcer Voice |