| Aired: | 02.27.2021 (1 / 13) |
| Aidy Bryant | ... | Ted Cruz |
| Pete Davidson | ... | Andrew Cuomo |
| Mikey Day | ... | Seymour Foreman |
| Heidi Gardner | ... | Jane F. |
| Steve Higgins | ... | announcer (voice) |
| Kate McKinnon | ... | Dr. Anthony Fauci |
| Alex Moffat | ... | Gavin Newsom |
| Ego Nwodim | ... | Kendall Frye |
| Cecily Strong | ... | Gretchen Whitmer |
| Melissa Villaseñor | ... | contestant |
| Bowen Yang | ... | Ronald |