| Cold Opening | So You Think You Can Get The Vaccine |
| Aidy Bryant | ... | Ted Cruz |
| Pete Davidson | ... | Andrew Cuomo Live |
| Mikey Day | ... | Seymour Foreman Live |
| Heidi Gardner | ... | Jane F. |
| Steve Higgins | ... | announcer Voice |
| Kate McKinnon | ... | Dr. Anthony Fauci Live |
| Alex Moffat | ... | Gavin Newsom Live |
| Ego Nwodim | ... | Kendall Frye |
| Cecily Strong | ... | Gretchen Whitmer Live |
| Melissa Villaseñor | ... | contestant |
| Bowen Yang | ... | Ronald |