| Sketch | A Rona Family Christmas |
| Timothée Chalamet | ... | Spike |
| Beck Bennett | ... | Rony |
| Andrew Dismukes | ... | boyfriend |
| Chloe Fineman | ... | Genital Herpes |
| Lauren Holt | ... | daughter |
| Cecily Strong | ... | mother |
| Melissa Villaseñor | ... | Spanish Influenza |
| Bowen Yang | ... | Oral Herpes |
| Steve Higgins | ... | announcer Voice |