| Cold Opening | Vice Presidential Debate |
| Jim Carrey | ... | Joe Biden#2 Live |
| Maya Rudolph | ... | Kamala Harris#5 |
| Beck Bennett | ... | Mike Pence#21 |
| Heidi Gardner | ... | Jill Biden |
| Kate McKinnon | ... | Susan Page |
| Kyle Mooney | ... | scientist |
| Kenan Thompson | ... | Herman Cain#7 Live |
| Steve Higgins | ... | announcer Voice |