| Cold Opening | Democratic Debate |
| Larry David | ... | Bernie Sanders Live |
| Rachel Dratch | ... | Amy Klobuchar Live |
| Jason Sudeikis | ... | Joe Biden Live |
| Pete Davidson | ... | Tom Steyer Live |
| Mikey Day | ... | George Stephanopoulos |
| Colin Jost | ... | Pete Buttigieg Live |
| Kate McKinnon | ... | Elizabeth Warren Live |
| Alex Moffat | ... | David Muir |
| Kenan Thompson | ... | audience member |
| Ego Nwodim | ... | Linsey Davis |
| Bowen Yang | ... | Andrew Yang Live |
| Steve Higgins | ... | announcer Voice |