May 21, 2016#1
| Cold Opening | Hillary & Bernie |
| Larry David | ... | Bernie Sanders |
| Vanessa Bayer | Live | |
| Beck Bennett | Live | |
| Aidy Bryant | Live | |
| Pete Davidson | Live | |
| Darrell Hammond | ... | Bill Clinton |
| Leslie Jones | Live | |
| Taran Killam | Live | |
| Kate McKinnon | ... | Hillary Clinton Live |
| Kyle Mooney | Live | |
| Bobby Moynihan | Live | |
| Jay Pharoah | Live | |
| Jon Rudnitsky | Live | |
| Cecily Strong | Live | |
| Kenan Thompson | ... | bartender |
| Sasheer Zamata | Live | |
| Bill Corsair | ... | pianist |