| Sketch | Roger Clemens Presents |
| Amy Adams | ... | Matt Mulgrew |
| Fred Armisen | ... | Maury |
| Will Forte | ... | doctor |
| Bill Hader | ... | Skip |
| Darrell Hammond | ... | reporter |
| Amy Poehler | ... | Salazar |
| Andy Samberg | ... | Timmy |
| Jason Sudeikis | ... | Roger Clemens |
| Kenan Thompson | ... | player |
| John Lutz | ... | director Voice |