| Cold Opening | Press Conference |
| Rachel Dratch | ... | Helen Thomas |
| Tina Fey | ... | Lori Donovan |
| Tracy Morgan | ... | Bo Bo Street News reporter |
| Chris Parnell | ... | George W. Bush Live |
| Amy Poehler | ... | Nicole Haggerton |
| Maya Rudolph | ... | Kathy Davis |
| Horatio Sanz | ... | Harry Knowles |
| Fred Armisen | ... | Reverend Phillips |
| Dean Edwards | ... | aide |
| Will Forte | ... | Kevin Miller |
| Seth Meyers | ... | Ted Vitner |
| Jeff Richards | ... | aide |
| Steve Higgins | ... | announcer Voice |
| Scott Wainio | ... | aide |