| Sketch | Moleculo “The Molecular Man” |
| Conan O'Brien | ... | Moleculo |
| Jimmy Fallon | ... | journalist |
| Darrell Hammond | ... | newspaper chief |
| Darrell Hammond | ... | narrator Voice |
| Chris Kattan | ... | gangster |
| Tracy Morgan | ... | gangster |
| Chris Parnell | ... | police officer |
| Horatio Sanz | ... | Mexican newspaper chief |
| Rachel Dratch | ... | journalist |
| Jerry Minor | ... | police officer |