| Sketch | The Pepsi Syndrome |
| Richard Benjamin | ... | Ross Denton |
| Rodney Dangerfield | ||
| Marvin Goldhar | ... | reporter |
| Dan Aykroyd | ... | Jimmy Carter |
| Jane Curtin | ... | Dr. Edna Casey |
| Garrett Morris | ... | Violet Crawford |
| Bill Murray | ... | Matt Crandall |
| Laraine Newman | ... | Rosalynn Carter |
| Gilda Radner | ... | Baba Wawa |
| Anne Beatts | ... | reporter |
| Tom Davis | ... | Two Mile player |
| Jim Downey | ... | reporter |
| Brian Doyle-Murray | ... | Carl |
| Al Franken | ... | Two Mile player |
| Lee Mayman | ... | reporter |
| Brian McConnachie | ||
| Nils Nichols | ... | reporter |
| Rosie Shuster | ... | reporter |
| Liz Welch | ... | reporter |
| Walter Williams | ... | reporter |
| Alan Zweibel | ... | reporter |