| Cold Opening | Republican Presidential Debate |
| Beck Bennett | ... | Jeb Bush#2 |
| Colin Jost | ... | John Kasich |
| Taran Killam | ... | Ted Cruz#3 |
| Kyle Mooney | ... | Rand Paul#2 |
| Bobby Moynihan | ... | Chris Christie#6 |
| Jay Pharoah | ... | Ben Carson#4 |
| Cecily Strong | ... | Carly Fiorina |
| Pete Davidson | ... | Marco Rubio#1 |
| Jon Rudnitsky | ... | Wolf Blitzer |
| Darrell Hammond | ... | Donald Trump#20 Live |
| Steve Higgins | ... | announcer Voice |
| Frank Anello | ... | audience member |