| Cold Opening | The Papal Debate |
| Fred Armisen | ... | Cardinal Dejakamo Live |
| Will Forte | ... | Cardinal Riccio |
| Darrell Hammond | ... | Tim Russert#5 |
| Seth Meyers | ... | translator Live |
| Chris Parnell | ... | Cardinal Rinaldi |
| Kenan Thompson | ... | Al Sharpton#3 |
| Steve Higgins | ... | announcer Voice |
| Phil Hymes | ... | Cardinal Urbino |