| Cold Opening | "Homeward Bound" |
| Clip Compilation | Physical Comedy |
| Miscellaneous | Audience Q&A |
| Film | Anxiety |
| Musical Performance | "Nothing Compares 2 U" |
| Film | The Stagehand |
| Musical Performance | "50 Years" |
| Clip Compilation | Commercial Parodies |
| Musical Performance | "Uproar" / "Lollipop" / "6 Foot 7 Foot" / "Mrs. Officer" / "A Milli" |
| Encore Presentation | Don't Look Back In Anger |
| Musical Performance | "Golden Slumbers" / "Carry That Weight" / "The End" |
| Monologue |
| Show |
| Fred Armisen | ... | Lawrence Welk |
| Will Ferrell | ... | Robert Goulet |
| Ana Gasteyer | ... | Margaret |
| Kenan Thompson | ... | Florian Trunt |
| Kristen Wiig | ... | Dooneese |
| Steve Higgins | ... | announcer Voice |
| Game Show |
| Leslie Jones | ... | Shanice |
| Tracy Morgan | ... | Darius |
| Eddie Murphy | ... | Tracy Morgan |
| Chris Rock | ||
| Kenan Thompson | ... | Darnell Hayes |
| Steve Higgins | ... | Johnny /announcer Voice |
| Sketch | Vow Renewal |
| Beck Bennett | ... | Scott |
| Andrew Dismukes | ... | Matthew |
| Chloe Fineman | ... | Kelsey |
| Heidi Gardner | ... | bridesmaid |
| Marcello Hernández | ... | Domingo |
| James Austin Johnson | ... | guest |
| Michael Longfellow | ... | guest |
| Kyle Mooney | ... | Scott |
| Ego Nwodim | ... | bridesmaid |
| Ashley Padilla | ... | guest |
| Andy Samberg | ... | Dale |
| Molly Shannon | ... | Kelsey's mother |
| Sarah Sherman | ... | bridesmaid |
| Martin Short | ... | Kelsey's father |
| Emil Wakim | ... | guest |
| Devon Walker | ... | guest |
| Jane Wickline | ... | guest |
| Bowen Yang | ... | Scott |
| Miscellaneous | Audience Q&A |
| Film | Anxiety |
| Weekend Update |
| Colin Jost | ||
| Michael Che | ||
| Cecily Strong | ... | The Girl You Wish You Hadn't Started A Conversation With At A Party |
| Bobby Moynihan | ... | Drunk Uncle |
| Seth Meyers | ||
| Vanessa Bayer | ... | Lorne's best friend from growing up |
| Fred Armisen | ... | Lorne's best friend from growing up |
| Bill Murray |
Ranks the Weekend Update anchors |
| Musical Sketch |
| Beck Bennett | ... | soldier |
| Billy Crystal | ||
| Pete Davidson | ||
| Chloe Fineman | ... | stockbroker |
| Will Forte | ... | Times Square Elmo |
| Ana Gasteyer | ... | pigeon |
| James Austin Johnson | ... | whiskey |
| Taran Killam | ... | pizza rat |
| Kate McKinnon | ... | Rudy Giuliani |
| Alex Moffat | ... | flasher |
| Kyle Mooney | ... | soldier |
| Maya Rudolph | ... | heroin |
| Maya Rudolph | ... | Lady Liberty |
| Paul Shaffer | ||
| Sarah Sherman | ... | Mike Bloomberg |
| David Spade | ||
| Ben Stiller | ||
| Cecily Strong | ... | cook |
| Jason Sudeikis | ... | singer |
| Kenan Thompson | ... | lobster |
| Emil Wakim | ... | Travis Bickle |
| Devon Walker | ... | Eric Adams |
| Kristen Wiig | ... | green M&M |
| John Mulaney | ||
| G.E. Smith |
| Sketch |
| Mikey Day | ... | kid |
| Will Ferrell | ... | Big Red |
| Marcello Hernández | ... | kid |
| Michael Longfellow | ... | kid |
| Eddie Murphy | ... | "All The Way" Ray May |
| Jason Sudeikis | ... | Officer Sikorsky |
| Kenan Thompson | ... | Lorenzo McIntosh |
| Musical Performance | "Uproar" / "Lollipop" / "6 Foot 7 Foot" / "Mrs. Officer" / "A Milli" |
| Miscellaneous | Audience Q&A |
| Sketch |
| Jon Hamm | ... | General Fairfax |
| Woody Harrelson | ... | Dusty |
| Pedro Pascal | ... | Kermit |
| Meryl Streep | ... | Colleen Rafferty Sr. |
| Musical Sketch |
| Adam Driver | ... | hot dog |
| Scarlett Johansson | ... | Audrey |
| Nick Jonas | ||
| Nathan Lane | ... | stockbroker |
| Lin-Manuel Miranda | ... | Alexander Hamilton |
| Paul Rudd | ... | Seymour |
| Musical Performance | "Golden Slumbers" / "Carry That Weight" / "The End" |
| Sketch | Vow Renewal |
| Andrew Dismukes | ... | Matthew |
| Chloe Fineman | ... | Kelsey |
| Heidi Gardner | ... | bridesmaid |
| Marcello Hernández | ... | Domingo |
| Ego Nwodim | ... | bridesmaid |
| Sarah Sherman | ... | bridesmaid |
| Monologue |
| Show |
| Scarlett Johansson | ... | Janice |
| Kim Kardashian | ... | Holly |
| Fred Armisen | ... | Lawrence Welk |
| Will Ferrell | ... | Robert Goulet |
| Ana Gasteyer | ... | Margaret |
| Kenan Thompson | ... | Florian Trunt |
| Kristen Wiig | ... | Dooneese |
| Steve Higgins | ... | announcer Voice |
| Game Show |
| Tom Hanks | ... | Doug |
| Leslie Jones | ... | Shanice |
| Tracy Morgan | ... | Darius |
| Eddie Murphy | ... | Tracy Morgan |
| Chris Rock | ||
| Kenan Thompson | ... | Darnell Hayes |
| Steve Higgins | ... | Johnny /announcer Voice |
| Clip Compilation | Physical Comedy |
| Sketch | Vow Renewal |
| Sabrina Carpenter | ... | Sophie |
| Bad Bunny | ... | Santiago |
| Pedro Pascal | ... | Renaldo |
| Beck Bennett | ... | Scott |
| Andrew Dismukes | ... | Matthew |
| Chloe Fineman | ... | Kelsey |
| Heidi Gardner | ... | bridesmaid |
| Marcello Hernández | ... | Domingo |
| James Austin Johnson | ... | guest |
| Michael Longfellow | ... | guest |
| Kyle Mooney | ... | Scott |
| Ego Nwodim | ... | bridesmaid |
| Ashley Padilla | ... | guest |
| Andy Samberg | ... | Dale |
| Molly Shannon | ... | Kelsey's mother |
| Sarah Sherman | ... | bridesmaid |
| Martin Short | ... | Kelsey's father |
| Emil Wakim | ... | guest |
| Devon Walker | ... | guest |
| Jane Wickline | ... | guest |
| Bowen Yang | ... | Scott |
| Miscellaneous | Audience Q&A |
| Film | Anxiety |
| Musical Performance | "Nothing Compares 2 U" |
| Weekend Update |
| Colin Jost | ||
| Michael Che | ||
| Cecily Strong | ... | The Girl You Wish You Hadn't Started A Conversation With At A Party |
| Bobby Moynihan | ... | Drunk Uncle |
| Seth Meyers | ||
| Vanessa Bayer | ... | Lorne's best friend from growing up |
| Fred Armisen | ... | Lorne's best friend from growing up |
| Bill Murray |
Ranks the Weekend Update anchors |
| Sketch |
| Jon Hamm | ... | General Fairfax |
| Woody Harrelson | ... | Dusty |
| Pedro Pascal | ... | Kermit |
| Meryl Streep | ... | Colleen Rafferty Sr. |
| Aidy Bryant | ... | Dr. Tyler |
| Kate McKinnon | ... | Colleen Rafferty |
| Musical Sketch |
| Adam Driver | ... | hot dog |
| Scarlett Johansson | ... | Audrey |
| Nick Jonas | ||
| Nathan Lane | ... | stockbroker |
| Lin-Manuel Miranda | ... | Alexander Hamilton |
| Paul Rudd | ... | Seymour |
| Beck Bennett | ... | soldier |
| Billy Crystal | ||
| Pete Davidson | ||
| Chloe Fineman | ... | stockbroker |
| Will Forte | ... | Times Square Elmo |
| Ana Gasteyer | ... | pigeon |
| James Austin Johnson | ... | whiskey |
| Taran Killam | ... | pizza rat |
| Kate McKinnon | ... | Rudy Giuliani |
| Alex Moffat | ... | flasher |
| Kyle Mooney | ... | soldier |
| Maya Rudolph | ... | heroin |
| Maya Rudolph | ... | Lady Liberty |
| Paul Shaffer | ||
| Sarah Sherman | ... | Mike Bloomberg |
| David Spade | ||
| Ben Stiller | ||
| Cecily Strong | ... | cook |
| Jason Sudeikis | ... | singer |
| Kenan Thompson | ... | lobster |
| Emil Wakim | ... | Travis Bickle |
| Devon Walker | ... | Eric Adams |
| Kristen Wiig | ... | green M&M |
| John Mulaney | ||
| G.E. Smith |
| Clip Compilation | Commercial Parodies |
| Musical Performance | "Uproar" / "Lollipop" / "6 Foot 7 Foot" / "Mrs. Officer" / "A Milli" |
| Sketch |
| Mikey Day | ... | kid |
| Will Ferrell | ... | Big Red |
| Marcello Hernández | ... | kid |
| Michael Longfellow | ... | kid |
| Eddie Murphy | ... | "All The Way" Ray May |
| Jason Sudeikis | ... | Officer Sikorsky |
| Kenan Thompson | ... | Lorenzo McIntosh |
| Encore Presentation | Don't Look Back In Anger |
| Musical Performance | "Golden Slumbers" / "Carry That Weight" / "The End" |